Alternative Folate Supplements for MTHFR

The Best Prenatals For MTHFR Mutations

If you have a significant mutation in the MTHFR gene, which encodes an enzyme that converts folate to the biologically active methylfolate, you may want to consider adding a stand-alone folate supplement to reach a higher dose of folate, and/or choosing a prenatal that has folate already in the methyl form.

MTHFR mutations have long been associated with recurrent miscarriage. A study published in May 2016 found that MTHFR mutations are also much more common in women with failed IVF cycles and chromosomally abnormal embryos. Your Doctor can order an MTHFR blood test or you can order DNA analysis yourself through 23andme and have the data analyzed through the free website Genetic Genie.

In years past, those with MTHFR mutations and either a history of miscarriage or neural tube defects were advised to take 4000 micrograms of synthetic folic acid to get around impaired folate metabolism. A newer approach is to use a folate that is already in the active form, called methylfolate.

Since many people may have MTHFR mutations without knowing it, some higher-quality supplement makers have switched the type of folate in their prenatal supplements to methylfolate (including Thorne ).

The only problem is that methylfolate can sometimes cause side effects such as mood changes and joint pain, particularly when taken in higher doses.  Therefore, if you have been advised to take a high dose of folate because of an MTHFR mutation, it may be best to take only part of that in the form of methylfolate (using a methyl-folate prenatal) and to take any additional folate in the form of natural folate, such as Country Life organic chewable Folate.  

Good prenatals containing L-methylfolate: